Spectrofotometrical determination of lipid peroxidation in brain of cadmium, nickel and zinc treated mice

Danguole Juciute, Rasa Bernotiene

Abstract


The present investigation was undertaken to evaluate the influence of Cd, Ni and Zn ions on the content of MDA (marker of lipid peroxidation) in mice brain. Experiments were done on outbreed white laboratory mice using intraperitoneal injections of CdCl2, NiCl2 and/or ZnSO4 solutions. The exposure time was 14 days. Our results showed that after 14 days the content of MDA was increased by 16% after exposure to Cd, by 73% after exposure to Zn and by 38% in Zn+Ni treated mice group. Meanwhile, in Zn+Cd and Ni treated mice groups, MDA content in mice brain was decreased by 27% and 19%, respectively, as compared to control mice group.

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BIOMEDICAL ENGINEERING CONFERENCE ORGANIZING COMMITEE,

BIOMEDICAL ENGINEERING INSTITUTE,

KAUNAS UNIVERSITY OF TECHNOLOGY.