Modification of NaYF4:Yb3+,Er3+ Up-Converting Nanoparticles with Phospholipid Coating for Cell Imaging

Ignas Jurciukonis, Urte Statkute, Ieva Mikalauskaite, Vilius Poderys, Vitalijus Karabanovas, Aldona Beganskiene, Ricardas Rotomskis

Abstract


UCNPs are widely studied due to possible applications in biomedical imaging and therapy. In this study we investigated NaYF4:Yb3+,Er3+ UCNPs as a potential nanomaterial for biomedical applications. We showed that UCNPs are photostable and do not degrade under prolonged exposure to NIR irradiation. Several surface modifications were tested using DOPC and PEG-DOPE phospholipids. Highest solubility in water was achieved when UCNPs were coated with the mixture of these lipids. NIH3T3 cells accumulated DOPC:PEG-DOPE-UCNPs and showed little to none viability decrease. UCNPs show potential  as fluorescent nanomaterial but this relatively new field requires further research to utilize upconverting nanoparticles in medical diagnostics and therapy.

 


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BIOMEDICAL ENGINEERING CONFERENCE ORGANIZING COMMITEE,

BIOMEDICAL ENGINEERING INSTITUTE,

KAUNAS UNIVERSITY OF TECHNOLOGY.