Sonoporation dosimetric evaluation from ultrasound signals attenuated by microbubbles

Martynas Maciulevicius

Abstract


New dosimetric estimate for ultrasound and microbubble assissted molecular delivery method (sonoporation) is presented in current study. Ultrasound signals, attenuated by cavitating microbubbles, were quantified as amplitude vs. time integral – „AMP dose“. The latter metric accurately (R2=0.97) predicts irreversible sonoporation to CHO cells, induced by microbubble cavitation in vitro, and holds promising prospects for future applications to dosimetric evaluation of molecular delivery.


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BIOMEDICAL ENGINEERING CONFERENCE ORGANIZING COMMITEE,

BIOMEDICAL ENGINEERING INSTITUTE,

KAUNAS UNIVERSITY OF TECHNOLOGY.