Ultrasound attenuation and scattering spectra relation with microbubbles sonodestruction and EtBr delivery in vitro

Rytis Jurkonis

Abstract


We are aiming to obtain dependence of sonotransfer efficiency of anticancer drug upon microbubble (MB) sonodestruction rate. The analysis of US attenuation and scattering spectrograms, time functions of amplitudes of attenuated and scattered pulses, MB sonodestruction as well as sonotransfer efficiency implies the following: 1) Sonotransfer efficiency show the consistent pattern with MB sonodestruction dynamics, however this relation is rather dependent on MB sonodestruction rate than of MB concentration; 2) The correlation of the MB sonodestruction intensity with the sonotransfer efficiency is dependent on the type of applied US.

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BIOMEDICAL ENGINEERING CONFERENCE ORGANIZING COMMITEE,

BIOMEDICAL ENGINEERING INSTITUTE,

KAUNAS UNIVERSITY OF TECHNOLOGY.