Liposome loaded doxorubicin delivery to cells via sonoporation

Abstract

In the current study sonoporation was employed as a method for doxorubicin loaded liposome delivery to Chinese hamster ovary cells. The liposomes were successfully synthesized and loaded with doxorubicin to the therapeutic amount. The therapeutic effect of doxorubicin loaded liposomes combined with cell sonoporation resulted in 10 % cell viability decrease. The obtained results are promising as they indicate anticancer drug transfer opportunity to cells via sonoporation, simultaneously avoiding side-effects, common for in vivo applications.