Sonoporation-mediated intracellular delivery dependence on molecule size

Abstract

Few experiments were done to investigate intracellular delivery by sonoporation dependence on molecular size, and the data are confusing. Some authors state that molecule size is important for intracellular delivery, while others found no dependence on molecular size. To solve this issue, we investigated two different molecule intracellular delivery under the same sonoporation parameters. One is small, 0.7 kDa propidium iodide; other is medium sized, 4 kDa FITC dextrane. Our results show that it was no difference between these two molecules intracellular delivery under the same sonoporation parameters.